HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P(1) to limit vascular inflammation

The sphingosine 1-phosphate receptor 1 (S1P(1)) is abundant in endothelial cells, where it regulates vascular development and microvascular barrier function. In investigating the role of endothelial cell S1P(1) in adult mice, we found that the endothelial S1P(1) signal was enhanced in regions of the...

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Publicat a:Sci Signal
Autors principals: Galvani, Sylvain, Sanson, Marie, Blaho, Victoria A., Swendeman, Steven L., Obinata, Hideru, Conger, Heather, Dahlbäck, Björn, Kono, Mari, Proia, Richard L., Smith, Jonathan D., Hla, Timothy
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768813/
https://ncbi.nlm.nih.gov/pubmed/26268607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa2581
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