HUMAN MASS BALANCE STUDY OF TAS-102 USING (14)C ANALYZED BY ACCELERATOR MASS SPECTROMETRY

BACKGROUND: TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite. TPI inhibits degradation of...

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書誌詳細
出版年:Cancer Chemother Pharmacol
主要な著者: Lee, James J., Seraj, Jabed, Yoshida, Kenichiro, Mizuguchi, Hirokazu, Strychor, Sandra, Fiejdasz, Jillian, Faulkner, Tyeler, Parise, Robert A., Fawcett, Patrick, Pollice, Laura, Mason, Scott, Hague, Jeremy, Croft, Marie, Nugteren, James, Tedder, Charles, Sun, Weijing, Chu, Edward, Beumer, Jan Hendrik
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767595/
https://ncbi.nlm.nih.gov/pubmed/26787503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-2965-2
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