HUMAN MASS BALANCE STUDY OF TAS-102 USING (14)C ANALYZED BY ACCELERATOR MASS SPECTROMETRY

BACKGROUND: TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite. TPI inhibits degradation of...

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Publicat a:Cancer Chemother Pharmacol
Autors principals: Lee, James J., Seraj, Jabed, Yoshida, Kenichiro, Mizuguchi, Hirokazu, Strychor, Sandra, Fiejdasz, Jillian, Faulkner, Tyeler, Parise, Robert A., Fawcett, Patrick, Pollice, Laura, Mason, Scott, Hague, Jeremy, Croft, Marie, Nugteren, James, Tedder, Charles, Sun, Weijing, Chu, Edward, Beumer, Jan Hendrik
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767595/
https://ncbi.nlm.nih.gov/pubmed/26787503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-2965-2
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