HUMAN MASS BALANCE STUDY OF TAS-102 USING (14)C ANALYZED BY ACCELERATOR MASS SPECTROMETRY

BACKGROUND: TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite. TPI inhibits degradation of...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Lee, James J., Seraj, Jabed, Yoshida, Kenichiro, Mizuguchi, Hirokazu, Strychor, Sandra, Fiejdasz, Jillian, Faulkner, Tyeler, Parise, Robert A., Fawcett, Patrick, Pollice, Laura, Mason, Scott, Hague, Jeremy, Croft, Marie, Nugteren, James, Tedder, Charles, Sun, Weijing, Chu, Edward, Beumer, Jan Hendrik
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767595/
https://ncbi.nlm.nih.gov/pubmed/26787503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-2965-2
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