HUMAN MASS BALANCE STUDY OF TAS-102 USING (14)C ANALYZED BY ACCELERATOR MASS SPECTROMETRY

BACKGROUND: TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite. TPI inhibits degradation of...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cancer Chemother Pharmacol
मुख्य लेखकों: Lee, James J., Seraj, Jabed, Yoshida, Kenichiro, Mizuguchi, Hirokazu, Strychor, Sandra, Fiejdasz, Jillian, Faulkner, Tyeler, Parise, Robert A., Fawcett, Patrick, Pollice, Laura, Mason, Scott, Hague, Jeremy, Croft, Marie, Nugteren, James, Tedder, Charles, Sun, Weijing, Chu, Edward, Beumer, Jan Hendrik
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767595/
https://ncbi.nlm.nih.gov/pubmed/26787503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-2965-2
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