HUMAN MASS BALANCE STUDY OF TAS-102 USING (14)C ANALYZED BY ACCELERATOR MASS SPECTROMETRY

BACKGROUND: TAS-102 is an oral fluoropyrimidine prodrug composed of trifluridine (FTD) and tipiracil hydrochloride (TPI) in a 1:0.5 ratio. FTD is a thymidine analog, and it is degraded by thymidine phosphorylase (TP) to the inactive trifluoromethyluracil (FTY) metabolite. TPI inhibits degradation of...

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Pubblicato in:Cancer Chemother Pharmacol
Autori principali: Lee, James J., Seraj, Jabed, Yoshida, Kenichiro, Mizuguchi, Hirokazu, Strychor, Sandra, Fiejdasz, Jillian, Faulkner, Tyeler, Parise, Robert A., Fawcett, Patrick, Pollice, Laura, Mason, Scott, Hague, Jeremy, Croft, Marie, Nugteren, James, Tedder, Charles, Sun, Weijing, Chu, Edward, Beumer, Jan Hendrik
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767595/
https://ncbi.nlm.nih.gov/pubmed/26787503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-2965-2
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