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Conformational Heterogeneity of the SAM-I Riboswitch Transcriptional ON State: A Chaperone-like Role for S-adenosylmethionine

Riboswitches are promising targets for the design of novel antibiotics and engineering of portable genetic regulatory elements. There is evidence that variability in riboswitch properties allows tuning of expression for genes involved in different stages of biosynthetic pathways by mechanisms that a...

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Pubblicato in:J Mol Biol
Autori principali: Huang, Wei, Kim, Joohyun, Jha, Shantenu, Aboul-ela, Fareed
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767528/
https://ncbi.nlm.nih.gov/pubmed/22425639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.02.019
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