The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells

Here we report that the PI3K/Akt1/IL-6/STAT3 signalling pathway regulates generation and stem cell-like properties of Non-Small Cell Lung Cancer (NSCLC) tumor initiating cells (TICs). Mutant Akt1, mutant PIK3CA or PTEN loss enhances formation of lung cancer spheroids (LCS), self-renewal, expression...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Malanga, Donatella, De Marco, Carmela, Guerriero, Ilaria, Colelli, Fabiana, Rinaldo, Nicola, Scrima, Marianna, Mirante, Teresa, De Vitis, Claudia, Zoppoli, Pietro, Ceccarelli, Michele, Riccardi, Miriam, Ravo, Maria, Weisz, Alessandro, Federico, Antonella, Franco, Renato, Rocco, Gaetano, Mancini, Rita, Rizzuto, Antonia, Gulletta, Elio, Ciliberto, Gennaro, Viglietto, Giuseppe
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767462/
https://ncbi.nlm.nih.gov/pubmed/26486080
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