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The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells
Here we report that the PI3K/Akt1/IL-6/STAT3 signalling pathway regulates generation and stem cell-like properties of Non-Small Cell Lung Cancer (NSCLC) tumor initiating cells (TICs). Mutant Akt1, mutant PIK3CA or PTEN loss enhances formation of lung cancer spheroids (LCS), self-renewal, expression...
Enregistré dans:
| Publié dans: | Oncotarget |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Impact Journals LLC
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4767462/ https://ncbi.nlm.nih.gov/pubmed/26486080 |
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