Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB

An intriguing biological question relating to cell signaling is how the inflammatory mediator NF-kB and the tumour suppressor protein p53 can be induced by similar triggers, like DNA damage or infection, yet have seemingly opposing or sometimes cooperative biological functions. For example, the NF-κ...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hu, Ying, Ge, Wenjie, Wang, Xingwen, Sutendra, Gopinath, Zhao, Kunming, Dedeić, Zinaida, Slee, Elizabeth A., Baer, Caroline, Lu, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767446/
https://ncbi.nlm.nih.gov/pubmed/26646590
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