iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death

Desmosomes are anchoring junctions that exist in cells that endure physical stress such as cardiac myocytes. The importance of desmosomes in maintaining the homeostasis of the myocardium is underscored by frequent mutations of desmosome components found in human patients and animal models. Arrhythmo...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Notari, Mario, Hu, Ying, Sutendra, Gopinath, Dedeić, Zinaida, Lu, Min, Dupays, Laurent, Yavari, Arash, Carr, Carolyn A., Zhong, Shan, Opel, Aaisha, Tinker, Andrew, Clarke, Kieran, Watkins, Hugh, Ferguson, David J. P., Kelsell, David P., de Noronha, Sofia, Sheppard, Mary N., Hollinshead, Mike, Mohun, Timothy J., Lu, Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352828/
https://ncbi.nlm.nih.gov/pubmed/25691752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408111112
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