iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death

Desmosomes are anchoring junctions that exist in cells that endure physical stress such as cardiac myocytes. The importance of desmosomes in maintaining the homeostasis of the myocardium is underscored by frequent mutations of desmosome components found in human patients and animal models. Arrhythmo...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Notari, Mario, Hu, Ying, Sutendra, Gopinath, Dedeić, Zinaida, Lu, Min, Dupays, Laurent, Yavari, Arash, Carr, Carolyn A., Zhong, Shan, Opel, Aaisha, Tinker, Andrew, Clarke, Kieran, Watkins, Hugh, Ferguson, David J. P., Kelsell, David P., de Noronha, Sofia, Sheppard, Mary N., Hollinshead, Mike, Mohun, Timothy J., Lu, Xin
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2015
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352828/
https://ncbi.nlm.nih.gov/pubmed/25691752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408111112
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