iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death

Desmosomes are anchoring junctions that exist in cells that endure physical stress such as cardiac myocytes. The importance of desmosomes in maintaining the homeostasis of the myocardium is underscored by frequent mutations of desmosome components found in human patients and animal models. Arrhythmo...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Notari, Mario, Hu, Ying, Sutendra, Gopinath, Dedeić, Zinaida, Lu, Min, Dupays, Laurent, Yavari, Arash, Carr, Carolyn A., Zhong, Shan, Opel, Aaisha, Tinker, Andrew, Clarke, Kieran, Watkins, Hugh, Ferguson, David J. P., Kelsell, David P., de Noronha, Sofia, Sheppard, Mary N., Hollinshead, Mike, Mohun, Timothy J., Lu, Xin
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352828/
https://ncbi.nlm.nih.gov/pubmed/25691752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408111112
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