iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death

Desmosomes are anchoring junctions that exist in cells that endure physical stress such as cardiac myocytes. The importance of desmosomes in maintaining the homeostasis of the myocardium is underscored by frequent mutations of desmosome components found in human patients and animal models. Arrhythmo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Notari, Mario, Hu, Ying, Sutendra, Gopinath, Dedeić, Zinaida, Lu, Min, Dupays, Laurent, Yavari, Arash, Carr, Carolyn A., Zhong, Shan, Opel, Aaisha, Tinker, Andrew, Clarke, Kieran, Watkins, Hugh, Ferguson, David J. P., Kelsell, David P., de Noronha, Sofia, Sheppard, Mary N., Hollinshead, Mike, Mohun, Timothy J., Lu, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352828/
https://ncbi.nlm.nih.gov/pubmed/25691752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408111112
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