Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma

Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functional behavior of which is guided by chemokine or cytokine gradients. Here, we retrospectively analyzed the expression patterns of 9 homing receptors (CCR/CXCR) in naive and memory CD4(+) and CD8(+) T lymphocyte...

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Publicado en:J Clin Invest
Autores principales: Jacquelot, Nicolas, Enot, David P., Flament, Caroline, Vimond, Nadège, Blattner, Carolin, Pitt, Jonathan M., Yamazaki, Takahiro, Roberti, María Paula, Daillère, Romain, Vétizou, Marie, Poirier-Colame, Vichnou, Semeraro, Michaëla, Caignard, Anne, Slingluff, Craig L., Sallusto, Federica, Rusakiewicz, Sylvie, Weide, Benjamin, Marabelle, Aurélien, Kohrt, Holbrook, Dalle, Stéphane, Cavalcanti, Andréa, Kroemer, Guido, Di Giacomo, Anna Maria, Maio, Michele, Wong, Phillip, Yuan, Jianda, Wolchok, Jedd, Umansky, Viktor, Eggermont, Alexander, Zitvogel, Laurence
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767356/
https://ncbi.nlm.nih.gov/pubmed/26854930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80071
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