Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Nonalcoholic steatohepatitis (NASH) is the most common liver disease in industrialized countries. NASH is a progressive disease that can lead to cirrhosis, cancer, and death, and there are currently no approved therapies. The development of NASH in animal models requires intact TLR9, but how the TLR...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Garcia-Martinez, Irma, Santoro, Nicola, Chen, Yonglin, Hoque, Rafaz, Ouyang, Xinshou, Caprio, Sonia, Shlomchik, Mark J., Coffman, Robert Lee, Candia, Albert, Mehal, Wajahat Zafar
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767345/
https://ncbi.nlm.nih.gov/pubmed/26808498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83885
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