Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Nonalcoholic steatohepatitis (NASH) is the most common liver disease in industrialized countries. NASH is a progressive disease that can lead to cirrhosis, cancer, and death, and there are currently no approved therapies. The development of NASH in animal models requires intact TLR9, but how the TLR...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Garcia-Martinez, Irma, Santoro, Nicola, Chen, Yonglin, Hoque, Rafaz, Ouyang, Xinshou, Caprio, Sonia, Shlomchik, Mark J., Coffman, Robert Lee, Candia, Albert, Mehal, Wajahat Zafar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767345/
https://ncbi.nlm.nih.gov/pubmed/26808498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83885
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