Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Nonalcoholic steatohepatitis (NASH) is the most common liver disease in industrialized countries. NASH is a progressive disease that can lead to cirrhosis, cancer, and death, and there are currently no approved therapies. The development of NASH in animal models requires intact TLR9, but how the TLR...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Garcia-Martinez, Irma, Santoro, Nicola, Chen, Yonglin, Hoque, Rafaz, Ouyang, Xinshou, Caprio, Sonia, Shlomchik, Mark J., Coffman, Robert Lee, Candia, Albert, Mehal, Wajahat Zafar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767345/
https://ncbi.nlm.nih.gov/pubmed/26808498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83885
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