Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Nonalcoholic steatohepatitis (NASH) is the most common liver disease in industrialized countries. NASH is a progressive disease that can lead to cirrhosis, cancer, and death, and there are currently no approved therapies. The development of NASH in animal models requires intact TLR9, but how the TLR...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Garcia-Martinez, Irma, Santoro, Nicola, Chen, Yonglin, Hoque, Rafaz, Ouyang, Xinshou, Caprio, Sonia, Shlomchik, Mark J., Coffman, Robert Lee, Candia, Albert, Mehal, Wajahat Zafar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2016
Onderwerpen:
Brief Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767345/
https://ncbi.nlm.nih.gov/pubmed/26808498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83885
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