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Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids

Covalent bond formations of free radical metabolites with biomolecules like DNA and proteins are thought to constitute a major mechanism of toxicity and carcinogenesis. Glutathione (GSH) is generally accepted as a radical scavenger protecting the cell. In the present study, we investigated a semiqui...

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Vydáno v:Environ Sci Pollut Res Int
Hlavní autoři: Wangpradit, Orarat, Rahaman, Asif, Mariappan, S. V. Santhana, Buettner, Garry R., Robertson, Larry W., Luthe, Gregor
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767158/
https://ncbi.nlm.nih.gov/pubmed/26396011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11356-015-5007-4
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