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Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids

Covalent bond formations of free radical metabolites with biomolecules like DNA and proteins are thought to constitute a major mechanism of toxicity and carcinogenesis. Glutathione (GSH) is generally accepted as a radical scavenger protecting the cell. In the present study, we investigated a semiqui...

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Detalhes bibliográficos
Publicado no:Environ Sci Pollut Res Int
Main Authors: Wangpradit, Orarat, Rahaman, Asif, Mariappan, S. V. Santhana, Buettner, Garry R., Robertson, Larry W., Luthe, Gregor
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767158/
https://ncbi.nlm.nih.gov/pubmed/26396011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11356-015-5007-4
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