A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with a high propensity to metastasize. Osteosarcoma is associated with massive genomic instability, making it problematic to identify driver genes using human tumors or prototypical mouse models, many of which invo...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Moriarity, Branden S, Otto, George M, Rahrmann, Eric P, Rathe, Susan K, Wolf, Natalie K, Weg, Madison T, Manlove, Luke A, LaRue, Rebecca S, Temiz, Nuri A, Molyneux, Sam D, Choi, Kwangmin, Holly, Kevin J, Sarver, Aaron L, Scott, Milcah C, Forster, Colleen L, Modiano, Jaime F, Khanna, Chand, Hewitt, Stephen M, Khokha, Rama, Yang, Yi, Gorlick, Richard, Dyer, Michael A, Largaespada, David A
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767150/
https://ncbi.nlm.nih.gov/pubmed/25961939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3293
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