Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and NFκB in rodent diabetic liver and relationships to hyperlipidemia and insulin resistance

Previous findings in diabetic rodents suggest that insulin activation of atypical protein kinase C (aPKC) is impaired in muscle, but surprisingly conserved in liver, despite impaired hepatic PKB/Akt activation. Moreover, aPKC at least partly regulates two major trans-activators, viz.,hepatic sterol...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Sajan, M. P., Standaert, M. L., Rivas, J., Miura, A., Kanoh, Y., Soto, J., Taniguchi, C.M., Kahn, C.R., Farese, R.V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766834/
https://ncbi.nlm.nih.gov/pubmed/19357831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-009-1336-5
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