Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

Most cell surface receptors for cytokines and growth factors signal as dimers, but it is unclear if remodeling receptor dimer topology is a viable strategy to ‘tune’ signaling output. We utilized diabodies (DA) as surrogate ligands in a prototypical dimeric receptor-ligand system, the cytokine Eryth...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Moraga, Ignacio, Wernig, Gerlinde, Wilmes, Stephan, Gryshkova, Vitalina, Richter, Christian Paolo, Hong, Wan-Jen, Sinha, Rahul, Guo, Feng, Fabionar, Hyna, Wehrman, Tom S., Krutzik, Peter, Demharter, Samuel, Plo, Isabelle, Weissman, Irving L., Minary, Peter, Majeti, Ravindra, Constantinescu, Stefan N., Piehler, Jacob, Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766813/
https://ncbi.nlm.nih.gov/pubmed/25728669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.011
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