Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1

INTRODUCTION: Insulin resistance and type 2 diabetes mellitus (T2D) are associated with increased risk for cognitive impairment, Alzheimer’s disease (AD) and vascular dementia. SORCS1 encodes a protein-sorting molecule genetically linked to both T2D and AD. The association of SORCS1 with both AD and...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Knight, Elysse M., Ruiz, Henry H., Kim, Soong Ho, Harte, Jessica C., Hsieh, Wilson, Glabe, Charles, Klein, William L., Attie, Alan D., Buettner, Christoph, Ehrlich, Michelle E., Gandy, Sam
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766719/
https://ncbi.nlm.nih.gov/pubmed/26916443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0282-y
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