Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27

BACKGROUND: KDM5B is a jmjc domain-containing histone demethylase which remove tri-, di-, and monomethyl groups from histone H3 lysine 4 (H3K4). KDM5B has been determined as an oncogene in many malignancies. However, its expression and role in hepatocellular carcinoma (HCC) remain unknown. METHODS:...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Wang, Dong, Han, Sheng, Peng, Rui, Jiao, Chenyu, Wang, Xing, Yang, Xinxiang, Yang, Renjie, Li, Xiangcheng
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766611/
https://ncbi.nlm.nih.gov/pubmed/26911146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0311-5
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