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Hemoglobin induced NO/cGMP suppression Deteriorate Microcirculation via Pericyte Phenotype Transformation after Subarachnoid Hemorrhage in Rats

Subarachnoid hemorrhage (SAH) usually results from ruptured aneurysm, but how leaked hemoglobin regulates the microcirculation in the pathophysiology of early brain injury after SAH is still unclear. In the present study, we sought to investigate the role and possible mechanism of hemoglobin induced...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Qiang, Chen, Yujie, Li, Bo, Luo, Chunxia, Zuo, Shilun, Liu, Xin, Zhang, John H., Ruan, Huaizhen, Feng, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766506/
https://ncbi.nlm.nih.gov/pubmed/26911739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22070
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