Hemoglobin induced NO/cGMP suppression Deteriorate Microcirculation via Pericyte Phenotype Transformation after Subarachnoid Hemorrhage in Rats

Subarachnoid hemorrhage (SAH) usually results from ruptured aneurysm, but how leaked hemoglobin regulates the microcirculation in the pathophysiology of early brain injury after SAH is still unclear. In the present study, we sought to investigate the role and possible mechanism of hemoglobin induced...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Li, Qiang, Chen, Yujie, Li, Bo, Luo, Chunxia, Zuo, Shilun, Liu, Xin, Zhang, John H., Ruan, Huaizhen, Feng, Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766506/
https://ncbi.nlm.nih.gov/pubmed/26911739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22070
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