Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent

β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selection also requires co-stimulatory signals from Notch receptor...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Westernberg, Luise, Conche, Claire, Huang, Yina Hsing, Rigaud, Stephanie, Deng, Yisong, Siegemund, Sabine, Mukherjee, Sayak, Nosaka, Lyn'Al, Das, Jayajit, Sauer, Karsten
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764578/
https://ncbi.nlm.nih.gov/pubmed/26880557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10786
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