Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there first has to be an available pool of intracellular am...

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Vydáno v:eLife
Hlavní autoři: Carroll, Bernadette, Maetzel, Dorothea, Maddocks, Oliver DK, Otten, Gisela, Ratcliff, Matthew, Smith, Graham R, Dunlop, Elaine A, Passos, João F, Davies, Owen R, Jaenisch, Rudolf, Tee, Andrew R, Sarkar, Sovan, Korolchuk, Viktor I
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764560/
https://ncbi.nlm.nih.gov/pubmed/26742086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11058
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