Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo

Human proinsulin with C-peptide–bearing Superfolder Green Fluorescent Protein (CpepSfGFP) has been expressed in transgenic mice, driven by the Ins1 promoter. The protein, expressed exclusively in β-cells, is processed and stored as CpepSfGFP and human insulin comprising only ∼0.04% of total islet pr...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Zhu, Shuaishuai, Larkin, Dennis, Lu, Shusheng, Inouye, Candice, Haataja, Leena, Anjum, Arfah, Kennedy, Robert, Castle, David, Arvan, Peter
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2016
Fag:
Islet Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764152/
https://ncbi.nlm.nih.gov/pubmed/26647386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1264
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