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Gonadotropin and kisspeptin gene expression, but not GnRH, are impaired in cFOS deficient mice

cFOS is a pleiotropic transcription factor, which binds to the AP1 site in the promoter of target genes. In the pituitary gonadotropes, cFOS mediates induction of FSHβ and GnRH receptor genes. Herein, we analyzed reproductive function in the cFOS-deficient mice to determine its role in vivo. In the...

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Detalhes bibliográficos
Publicado no:Mol Cell Endocrinol
Main Authors: Xie, Changchuan, Jonak, Carrie R., Kauffman, Alexander S., Coss, Djurdjica
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764054/
https://ncbi.nlm.nih.gov/pubmed/25958044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2015.04.033
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