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Crystal structures of penicillin‐binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms

Penicillin‐binding protein 3 (PBP3) from Pseudomonas aeruginosa is the molecular target of β‐lactam‐based antibiotics. Structures of PBP3 in complexes with azlocillin and cefoperazone, which are in clinical use for the treatment of pseudomonad infections, have been determined to 2.0 Å resolution. To...

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Dades bibliogràfiques
Publicat a:FEBS Lett
Autors principals: Ren, Jingshan, Nettleship, Joanne E., Males, Alexandra, Stuart, David I., Owens, Raymond J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764023/
https://ncbi.nlm.nih.gov/pubmed/26823174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12054
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