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Crystal structures of penicillin‐binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms

Penicillin‐binding protein 3 (PBP3) from Pseudomonas aeruginosa is the molecular target of β‐lactam‐based antibiotics. Structures of PBP3 in complexes with azlocillin and cefoperazone, which are in clinical use for the treatment of pseudomonad infections, have been determined to 2.0 Å resolution. To...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Ren, Jingshan, Nettleship, Joanne E., Males, Alexandra, Stuart, David I., Owens, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764023/
https://ncbi.nlm.nih.gov/pubmed/26823174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12054
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