Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Autophagy is an essential component of innate immunity, enabling the detection and elimination of intracellular pathogens. Legionella pneumophila, an intracellular pathogen that can cause a severe pneumonia in humans, is able to modulate autophagy through the action of effector proteins that are tra...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Rolando, Monica, Escoll, Pedro, Nora, Tamara, Botti, Joëlle, Boitez, Valérie, Bedia, Carmen, Daniels, Craig, Abraham, Gilu, Stogios, Peter J., Skarina, Tatiana, Christophe, Charlotte, Dervins-Ravault, Delphine, Cazalet, Christel, Hilbi, Hubert, Rupasinghe, Thusitha W. T., Tull, Dedreia, McConville, Malcolm J., Ong, Sze Ying, Hartland, Elizabeth L., Codogno, Patrice, Levade, Thierry, Naderer, Thomas, Savchenko, Alexei, Buchrieser, Carmen
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763766/
https://ncbi.nlm.nih.gov/pubmed/26831115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522067113
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