Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Autophagy is an essential component of innate immunity, enabling the detection and elimination of intracellular pathogens. Legionella pneumophila, an intracellular pathogen that can cause a severe pneumonia in humans, is able to modulate autophagy through the action of effector proteins that are tra...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rolando, Monica, Escoll, Pedro, Nora, Tamara, Botti, Joëlle, Boitez, Valérie, Bedia, Carmen, Daniels, Craig, Abraham, Gilu, Stogios, Peter J., Skarina, Tatiana, Christophe, Charlotte, Dervins-Ravault, Delphine, Cazalet, Christel, Hilbi, Hubert, Rupasinghe, Thusitha W. T., Tull, Dedreia, McConville, Malcolm J., Ong, Sze Ying, Hartland, Elizabeth L., Codogno, Patrice, Levade, Thierry, Naderer, Thomas, Savchenko, Alexei, Buchrieser, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763766/
https://ncbi.nlm.nih.gov/pubmed/26831115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522067113
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