Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood

The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old he...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nakaya, Helder I., Clutterbuck, Elizabeth, Kazmin, Dmitri, Wang, Lili, Cortese, Mario, Bosinger, Steven E., Patel, Nirav B., Zak, Daniel E., Aderem, Alan, Dong, Tao, Del Giudice, Giuseppe, Rappuoli, Rino, Cerundolo, Vincenzo, Pollard, Andrew J., Pulendran, Bali, Siegrist, Claire-Anne
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763735/
https://ncbi.nlm.nih.gov/pubmed/26755593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519690113
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