Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns

Post-translational modifications (PTMs) of histone proteins play a fundamental role in regulation of DNA-templated processes. There is also growing evidence that proteolytic cleavage of histone N-terminal tails, known as histone clipping, influences nucleosome dynamics and functional properties. Usi...

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Détails bibliographiques
Publié dans:Mol Cell Proteomics
Auteurs principaux: Tvardovskiy, Andrey, Wrzesinski, Krzysztof, Sidoli, Simone, Fey, Stephen J., Rogowska-Wrzesinska, Adelina, Jensen, Ole N.
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762630/
https://ncbi.nlm.nih.gov/pubmed/26424599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.048975
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