Endothelial Cell Proteomic Response to Rickettsia conorii Infection Reveals Activation of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT)-Inferferon Stimulated Gene (ISG)15 Pathway and Reprogramming Plasma Membrane Integrin/Cadherin Signaling

Rickettsia conorii is the etiologic agent of Mediterranean spotted fever, a re-emerging infectious disease with significant mortality. This Gram-negative, obligately intracellular pathogen is transmitted via tick bites, resulting in disseminated vascular endothelial cell infection with vascular leak...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Zhao, Yingxin, Valbuena, Gustavo, Walker, David H., Gazi, Michal, Hidalgo, Marylin, DeSousa, Rita, Oteo, Jose Antonio, Goez, Yenny, Brasier, Allan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762516/
https://ncbi.nlm.nih.gov/pubmed/26560068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.054361
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