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Discovery of novel cross-protective Rickettsia prowazekii T-cell antigens using a combined reverse vaccinology and in vivo screening approach

Rickettsial agents are some of the most lethal pathogens known to man. Among them, Rickettsia prowazekii is a select agent with potential use for bioterrorism; yet, there is no anti-Rickettsia vaccine commercially available. Owing to the obligate intracellular lifestyle of rickettsiae, CD8(+) T cell...

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Detalhes bibliográficos
Main Authors: Caro-Gomez, Erika, Gazi, Michal, Goez, Yenny, Valbuena, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145598/
https://ncbi.nlm.nih.gov/pubmed/25010827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.06.089
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