CryoEM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

U4/U6.U5 tri-snRNP represents a substantial part of the spliceosome before activation. A cryoEM structure of Saccharomyces cerevisiae U4/U6.U5 tri-snRNP at 3.7Å resolution led to an essentially complete atomic model comprising 30 proteins plus U4/U6 and U5 snRNAs. The structure reveals striking inte...

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Udgivet i:Nature
Main Authors: Nguyen, Thi Hoang Duong, Galej, Wojciech P., Bai, Xiao-chen, Oubridge, Chris, Newman, Andrew J., Scheres, Sjors H. W., Nagai, Kiyoshi
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762201/
https://ncbi.nlm.nih.gov/pubmed/26829225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16940
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