Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy

Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, the cytokine leptin has been associated to breast carcinogenesis. The nuclea...

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מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Giordano, Cinzia, Barone, Ines, Vircillo, Valentina, Panza, Salvatore, Malivindi, Rocco, Gelsomino, Luca, Pellegrino, Michele, Rago, Vittoria, Mauro, Loredana, Lanzino, Marilena, Panno, Maria Luisa, Bonofiglio, Daniela, Catalano, Stefania, Andò, Sebastiano
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2016
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761870/
https://ncbi.nlm.nih.gov/pubmed/26899873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21782
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