Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy

Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, the cytokine leptin has been associated to breast carcinogenesis. The nuclea...

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Published in:Sci Rep
Main Authors: Giordano, Cinzia, Barone, Ines, Vircillo, Valentina, Panza, Salvatore, Malivindi, Rocco, Gelsomino, Luca, Pellegrino, Michele, Rago, Vittoria, Mauro, Loredana, Lanzino, Marilena, Panno, Maria Luisa, Bonofiglio, Daniela, Catalano, Stefania, Andò, Sebastiano
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761870/
https://ncbi.nlm.nih.gov/pubmed/26899873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21782
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