Phosphodiesterase 5 (PDE5) Is Highly Expressed in Cancer-Associated Fibroblasts and Enhances Breast Tumor Progression

The overexpression of phosphodiesterase (PDE) 5 is frequently found in various human cancers, such as those of the breast. However, PDE5’s role in the tumor microenvironment is still unknown. As PDE5 represents a high-value therapeutic target, we investigated whether the expression and fun...

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Detalhes bibliográficos
Main Authors: Stefania Catalano, Salvatore Panza, Giuseppina Augimeri, Cinzia Giordano, Rocco Malivindi, Luca Gelsomino, Stefania Marsico, Francesca Giordano, Balázs Győrffy, Daniela Bonofiglio, Sebastiano Andò, Ines Barone
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-11-01
Colecção:Cancers
Assuntos:
breast cancer
pde5
tumor microenvironment
targeted therapy
cxcl16
Acesso em linha:https://www.mdpi.com/2072-6694/11/11/1740
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