Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy

Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, the cytokine leptin has been associated to breast carcinogenesis. The nuclea...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Giordano, Cinzia, Barone, Ines, Vircillo, Valentina, Panza, Salvatore, Malivindi, Rocco, Gelsomino, Luca, Pellegrino, Michele, Rago, Vittoria, Mauro, Loredana, Lanzino, Marilena, Panno, Maria Luisa, Bonofiglio, Daniela, Catalano, Stefania, Andò, Sebastiano
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761870/
https://ncbi.nlm.nih.gov/pubmed/26899873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21782
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