Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy

Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, the cytokine leptin has been associated to breast carcinogenesis. The nuclea...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Giordano, Cinzia, Barone, Ines, Vircillo, Valentina, Panza, Salvatore, Malivindi, Rocco, Gelsomino, Luca, Pellegrino, Michele, Rago, Vittoria, Mauro, Loredana, Lanzino, Marilena, Panno, Maria Luisa, Bonofiglio, Daniela, Catalano, Stefania, Andò, Sebastiano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761870/
https://ncbi.nlm.nih.gov/pubmed/26899873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21782
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