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Small molecule therapeutics targeting F-Box proteins in cancer
The ubiquitin proteasome system (UPS) plays vital roles in maintaining protein equilibrium mainly through proteolytic degradation of targeted substrates. The archetypical SCF ubiquitin E3 ligase complex contains a substrate recognition subunit F-box protein that recruits substrates to the catalytic...
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| Publicado no: | Semin Cancer Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4761489/ https://ncbi.nlm.nih.gov/pubmed/26427329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2015.09.014 |
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