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The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin

Fbxl7, a component of the Skp1·Cul1·F-box protein type ubiquitin E3 ligase, regulates mitotic cell cycle progression. Here we demonstrate that overexpression of Fbxl7 in lung epithelia decreases the protein abundance of survivin, a member of the inhibitor of apoptosis family. Fbxl7 mediates polyubiq...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liu, Yuan, Lear, Travis, Iannone, Olivia, Shiva, Sruti, Corey, Catherine, Rajbhandari, Shristi, Jerome, Jacob, Chen, Bill B., Mallampalli, Rama K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424325/
https://ncbi.nlm.nih.gov/pubmed/25778398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.629931
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