Selective Bottlenecks Shape Evolutionary Pathways Taken during Mammalian Adaptation of a 1918-like Avian Influenza Virus

Avian influenza virus reassortants resembling the 1918 human pandemic virus can become transmissible among mammals by acquiring mutations in hemagglutinin (HA) and polymerase. Using the ferret model, we trace the evolutionary pathway by which an avian-like virus evolves the capacity for mammalian re...

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Bibliografske podrobnosti
izdano v:Cell Host Microbe
Main Authors: Moncla, Louise H., Zhong, Gongxun, Nelson, Chase W., Dinis, Jorge M., Mutschler, James, Hughes, Austin L., Watanabe, Tokiko, Kawaoka, Yoshihiro, Friedrich, Thomas C.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Inc. 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761429/
https://ncbi.nlm.nih.gov/pubmed/26867176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.01.011
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