Selective Bottlenecks Shape Evolutionary Pathways Taken during Mammalian Adaptation of a 1918-like Avian Influenza Virus

Avian influenza virus reassortants resembling the 1918 human pandemic virus can become transmissible among mammals by acquiring mutations in hemagglutinin (HA) and polymerase. Using the ferret model, we trace the evolutionary pathway by which an avian-like virus evolves the capacity for mammalian re...

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Publicado en:Cell Host Microbe
Main Authors: Moncla, Louise H., Zhong, Gongxun, Nelson, Chase W., Dinis, Jorge M., Mutschler, James, Hughes, Austin L., Watanabe, Tokiko, Kawaoka, Yoshihiro, Friedrich, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Inc. 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761429/
https://ncbi.nlm.nih.gov/pubmed/26867176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.01.011
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