Pharmacological characterization of the opioid inactive isomers (+)‐naltrexone and (+)‐naloxone as antagonists of toll‐like receptor 4

BACKGROUND AND PURPOSE: The toll‐like receptor TLR4 is involved in neuropathic pain and in drug reward and reinforcement. The opioid inactive isomers (+)‐naltrexone and (+)‐naloxone act as TLR4 antagonists, reversing neuropathic pain and reducing opioid and cocaine reward and reinforcement. However,...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Wang, X, Zhang, Y, Peng, Y, Hutchinson, M R, Rice, K C, Yin, H, Watkins, L R
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761092/
https://ncbi.nlm.nih.gov/pubmed/26603732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13394
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