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Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation

Most metazoan E3 ligases contain a signature RING domain that promotes the transfer of ubiquitin from the active site of E2 conjugating enzymes to lysine residues in substrates. Although these RING-E3s depend on E2 enzymes for catalysis, how they turn on their E2s at the right time and place remains...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Craney, Allison, Kelly, Aileen, Jia, Luying, Fedrigo, Indro, Yu, Hongtao, Rape, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760819/
https://ncbi.nlm.nih.gov/pubmed/26811472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522423113
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