Pimaradienoic Acid Inhibits Carrageenan-Induced Inflammatory Leukocyte Recruitment and Edema in Mice: Inhibition of Oxidative Stress, Nitric Oxide and Cytokine Production

Pimaradienoic acid (PA; ent-pimara-8(14),15-dien-19-oic acid) is a pimarane diterpene found in plants such as Vigueira arenaria Baker (Asteraceae) in the Brazilian savannas. Although there is evidence on the analgesic and in vitro inhibition of inflammatory signaling pathways, and paw edema by PA, i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mizokami, Sandra S., Hohmann, Miriam S. N., Staurengo-Ferrari, Larissa, Carvalho, Thacyana T., Zarpelon, Ana C., Possebon, Maria I., de Souza, Anderson R., Veneziani, Rodrigo C. S., Arakawa, Nilton S., Casagrande, Rubia, Verri, Waldiceu A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760730/
https://ncbi.nlm.nih.gov/pubmed/26895409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149656
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