Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−K(ATP)Channel Signaling Pathway

In the present study, the effect and mechanism of action of the flavonoid naringenin were evaluated in superoxide anion donor (KO(2))-induced inflammatory pain in mice. Naringenin reduced KO(2)-induced overt-pain like behavior, mechanical hyperalgesia, and thermal hyperalgesia. The analgesic effect...

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Foilsithe in:PLoS One
Main Authors: Manchope, Marília F., Calixto-Campos, Cássia, Coelho-Silva, Letícia, Zarpelon, Ana C., Pinho-Ribeiro, Felipe A., Georgetti, Sandra R., Baracat, Marcela M., Casagrande, Rúbia, Verri, Waldiceu A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821586/
https://ncbi.nlm.nih.gov/pubmed/27045367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153015
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