Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

Aggressive double- and triple-hit (DH/TH) diffuse large B-cell lymphomas (DLBCLs) feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls posttranscriptional dynamics of key messenger RNA (mRNA) species including those encoding BCL6, MYC, and BCL2. Using a proteomics approac...

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發表在:Blood
Main Authors: Culjkovic-Kraljacic, Biljana, Fernando, Tharu M., Marullo, Rossella, Calvo-Vidal, Nieves, Verma, Akanksha, Yang, ShaoNing, Tabbò, Fabrizio, Gaudiano, Marcello, Zahreddine, Hiba, Goldstein, Rebecca L., Patel, Jayeshkumar, Taldone, Tony, Chiosis, Gabriela, Ladetto, Marco, Ghione, Paola, Machiorlatti, Rodolfo, Elemento, Olivier, Inghirami, Giorgio, Melnick, Ari, Borden, Katherine L. B., Cerchietti, Leandro
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2016
主題:
Lymphoid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760090/
https://ncbi.nlm.nih.gov/pubmed/26603836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-645069
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