Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

Aggressive double- and triple-hit (DH/TH) diffuse large B-cell lymphomas (DLBCLs) feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls posttranscriptional dynamics of key messenger RNA (mRNA) species including those encoding BCL6, MYC, and BCL2. Using a proteomics approac...

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Udgivet i:Blood
Main Authors: Culjkovic-Kraljacic, Biljana, Fernando, Tharu M., Marullo, Rossella, Calvo-Vidal, Nieves, Verma, Akanksha, Yang, ShaoNing, Tabbò, Fabrizio, Gaudiano, Marcello, Zahreddine, Hiba, Goldstein, Rebecca L., Patel, Jayeshkumar, Taldone, Tony, Chiosis, Gabriela, Ladetto, Marco, Ghione, Paola, Machiorlatti, Rodolfo, Elemento, Olivier, Inghirami, Giorgio, Melnick, Ari, Borden, Katherine L. B., Cerchietti, Leandro
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760090/
https://ncbi.nlm.nih.gov/pubmed/26603836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-645069
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