Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

Aggressive double- and triple-hit (DH/TH) diffuse large B-cell lymphomas (DLBCLs) feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls posttranscriptional dynamics of key messenger RNA (mRNA) species including those encoding BCL6, MYC, and BCL2. Using a proteomics approac...

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Foilsithe in:Blood
Main Authors: Culjkovic-Kraljacic, Biljana, Fernando, Tharu M., Marullo, Rossella, Calvo-Vidal, Nieves, Verma, Akanksha, Yang, ShaoNing, Tabbò, Fabrizio, Gaudiano, Marcello, Zahreddine, Hiba, Goldstein, Rebecca L., Patel, Jayeshkumar, Taldone, Tony, Chiosis, Gabriela, Ladetto, Marco, Ghione, Paola, Machiorlatti, Rodolfo, Elemento, Olivier, Inghirami, Giorgio, Melnick, Ari, Borden, Katherine L. B., Cerchietti, Leandro
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2016
Ábhair:
Lymphoid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760090/
https://ncbi.nlm.nih.gov/pubmed/26603836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-645069
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